Development of structural and functional compartments in neurons. The intricate organization of the nervous system relies on the subcellular compartmentalization of every neuron. My lab studies how distinct subcellular compartments are established in neurons and how this process contributes to forming the neural circuits. We are particularly interested in the differential development between dendrites and axons and the strategic distribution of synapses in neurons. We employ a multi-disciplinary approach, including genetics, molecular biology, biochemistry, and advanced multi-dimensional imaging, to study these problems in both Drosophila and mammals. Our studies provide critical insights to the assembly, function, plasticity, and disorders of the nervous system.